Normally means a fault with the coupler is preventing it running in multiple from that end only, ie the other end is still OK.
Often seen on EMUs▸ , some depots put up a label saying 'Non Mult' or similar.
Paul
Can also be for problems with alignment of through gangways if a particular vehicle has suspension issues.
If you've seen more of them recently it's probably due to a snow build up inside the coupler.